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Scientific Awards

William B. Coley Award for Distinguished Research in Basic and Tumor Immunology 

Glen N. Barber PhD. FRS. 2020 Award Recipient

Fellow of the Royal Society (FRS), London, 2021

Glen N. Barber PhD, FRS. 2021

Select Publications

Ahn J, Xia T, Rabasa Capote A, Betancourt D, Barber GN. Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. Cancer Cell. 2018 May 14;33(5):862-873.e5. doi: 10.1016/j.ccell.2018.03.027. Epub 2018 Apr 26. PMID: 29706455

Russell SJ, Barber GN. Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines. Cancer Cell. 2018 Apr 9;33(4):599-605. doi: 10.1016/j.ccell.2018.03.011. Review. PMID: 29634947

Ahn J, Son S, Oliveira SC, Barber GN. STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. Cell Reports. 2017 Dec 26;21(13):3873-3884. doi: 10.1016/ j.celrep.2017.11.101. PMID: 29281834

Swanson KV, Junkins RD, Kurkjian CJ, Holley-Guthrie E, Pendse AA, El Morabiti R, Petrucelli A, Barber GN, Benedict CA, Ting JP. A noncanonical function of cGAMP in inflammasome priming and activation. Journal of Experimental Medicine. 2017 Dec 4;214(12):3611-3626. doi: 10.1084/jem.20171749. Epub 2017Oct 13. PMID: 29030458

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017 Oct 4. doi: 10.1038/nature24050 PMID: 28976970

Ni G, Konno H, Barber, GN. Ubiquitination of STING at lysine 224 controls IRF3 activation. Science Immunology. 2017 May 5;2(11). pii: eaah7119. doi: 10.1126/sciimmunol.aah7119. PMID: 28763789

Xia T, Konno H, Barber, GN. Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis. Cancer Research 2016, Nov 15;76(22):6747-6759. doi: 10.1158/0008-5472.CAN-16-1404. Epub 2016 Sep 28. PMID: 27680683

Xia T, Konno H, Ahn J, Barber, GN. Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA-Damage Responses and Correlates With Tumorigenesis. Cell Reports. 2016 Jan;14(2):282-97. doi:10.2016/j.celrep.2015.12.029. PubMed PMID: 26748708.

Barber GN. STING: infection, inflammation and cancer. Nature Review Immunology. 2015 Dec;15(12):760-70. doi: 10.1038/nri3921. PubMed

PMID: 26603901

Betancourt D, Ramos JC, Barber GN. Retargeting Oncolytic Vesicular Stomatitis Virus to    Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia. Journal of Virology. 2015 Dec;89(23):11786-800. doi: 10.1128/JVI.01356-15. PubMed PMID: 26378177.

Ahn J, Konno H, Barber GN. Diverse roles of STING-dependent signaling on the development of cancer. Oncogene. 2015 Oct. doi: 10.1038/onc.2014.457. PubMed PMID: 25639870.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B. Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses. Proceedings of the National Academy of Sciences of the United States of America. 2015 Aug;112(31):E4306-15. doi: 10.1073/pnas.1503831112. PubMed PMID: 26199418; PubMed Central PMCID: PMC4534226.

Hyun J, Ramos JC, Toomey N, Balachandran S, Lavorgna A, Harhaj E, Barber GN. Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways. Journal of Virology. 2015 May;89(9):4880-93. doi: 10.1128/JVI.02493-14. PubMed PMID: 25694597.

Ahn J, Barber GN. Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease. Current opinion in immunology. 2014 Dec.;31:121-6. doi: 10.1016/j.coi.2014.10.009. PubMed PMID: 25459004.

 

Ahn J, Ruiz P, Barber GN. Intrinsic Self-DNA triggers inflammatory disease dependent on STING. Journal of Immunology. 2014 Nov;193(9):4634-42. doi: 10.4049/jimmunol.1401337. PubMed PMID: 25261479.

Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014;41(5):830-42. doi: 10.1016/j.immuni.2014.10.017. PubMed PMID: 25517615; PubMed Central PMCID: PMC4384884.

Ahn J, Xia T, Konno H, Konno K, Ruiz P, Barber GN. Inflammation-driven carcinogenesis is mediated through STING. Nature Communications. 2014 Oct;5:5166. doi: 10.1038/ncomms6166. PubMed PMID: 25300616.

Barber GN. STING-dependent cytosolic DNA sensing pathways. Trends in Immunology. 2014 Feb.;35(2):88-93. Epub 2013/12/07. doi: 10.1016/j.it.2013.10.010. PubMed PMID: 24309426.

Konno H, Konno K, Barber GN. Cyclic Di Nucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling. Cell. 2013 Oct. doi: 10.1016/j.cell.2013.09.049. PubMed PMID: 24119841.

Abe T, Harashima A, Xia T, Konno H, Konno K, Morales A, Ahn J, Gutman D, Barber GN. STING recognition of cytoplasmic DNA instigates cellular defense. Molecular Cell. 2013;50(1):5-15. doi: 10.1016/j.molcel.2013 April.01.039. PubMed PMID: 23478444.

Ahn J, Gutman D, Saijo S, Barber GN. STING manifests self DNA-dependent inflammatory disease. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov;109(47):19386-91. doi: 10.1073/pnas.1215006109. PubMed PMID: 23132945; PubMed Central PMCID: PMC3511090.

Barber GN. STING-dependent signaling. Nature Immunology. 2011 Sep 20;12(10):929-30. doi: 10.1038/ni.2118. Erratum in: Nat Immunol. 2012 Feb;13(2):196. PMID: 21934672.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M, Jr., Barber GN, Stetson DB. Autoimmunity initiates in non-hematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012 Jan.;36(1):120-31. doi: 10.1016/j.immuni.2011.11.018. PubMed PMID: 22284419; PubMed Central PMCID: PMC3269499.

Heiber JF, Barber GN. Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent. Journal of Virology. 2011 Oct.;85(20):10440-50. doi: 10.1128/JVI.05408-11. PubMed PMID: 21813611; PubMed Central PMCID: PMC3187518.

Elsby R, Heiber JF, Reid P, Kimball SR, Pavitt GD, Barber GN. The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus. Journal of Virology. 2011 Oct.;85(19):9716-25. doi: 10.1128/JVI.05146-11. PubMed PMID: 21795329; PubMed Central PMCID: PMC3196436.

Barber GN. Cytoplasmic DNA innate immune pathways. Immunological Reviews. 2011 Sep;243(1):99-108. doi: 10.1111/j.1600-065X.2011.01051.x. Review. PMID: 21884170

Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.Immunity. 2011 Aug 26;35(2):194-207. doi: 10.1016/j.immuni.2011.05.016. Epub 2011 Aug 4. PMID: 21820332.

 

Barber GN. (2011). Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol, 2011 Feb;23(1):10-20. PMID: 21239155

Harashima A, Guettouche T, Barber GN. Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. Genes & Development. 2010 Dec.;24(23):2640-53. doi: 10.1101/gad.1965010. PubMed

PMID: 21123651; PubMed Central PMCID: PMC2994038.

Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009 Oct.;461(7265):788-92. doi: 10.1038/nature08476. PubMed PMID: 19776740.

Ishikawa H, Barber GN. STING an endoplasmic reticulum adaptor that facilitates innate immune signaling. Nature. 2008 Oct.;455(7213):674-8. doi: 10.1038/nature07317. PubMed PMID: 18724357; PubMed Central PMCID: PMC2804933.

Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BM, Martin WD, Barber GN. NFAR-1 and -2 modulate translation and are required for efficient host defense. Proceedings of the National Academy of Sciences of the United States of America. 2008 March ;105(11):4173-8. doi: 10.1073/pnas.0711222105. PubMed PMID: 18337511; PubMed Central PMCID: PMC2393807.

Majid AM, Ezelle H, Shah S, Barber GN. Evaluating replication-defective vesicular stomatitis virus as a vaccine vehicle. Journal of Virology. 2006 July;80(14):6993-7008. doi: 10.1128/JVI.00365-06. PubMed PMID: 16809305; PubMed Central PMCID: PMC1489030.

Balachandran S, Thomas E, Barber GN. A FADD-dependent innate immune mechanism in mammalian cells. Nature. 2004 Nov;432(7015):401-5. doi: 10.1038/nature03124. PubMed PMID: 15549108.

Balachandran S, Barber GN. Defective translational control facilitates vesicular stomatitis virus oncolysis. Cancer Cell. 2004 Jan;5(1):51-65. PubMed

PMID: 14749126.

Obuchi M, Fernandez M, Barber GN. Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity. Journal of Virology. 2003 Aug;77(16):8843-56. PubMed PMID: 12885903; PubMed Central PMCID: PMC167243.

Fernandez M, Porosnicu M, Markovic D, Barber GN. Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease. Journal of Virology. 2002 Jan;76(2):895-904. PubMed PMID: 11752178; PubMed Central PMCID: PMC136833.

Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN. Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. The Journal of Biological Chemistry. 2001 Aug;276(34):32300-12. doi: 10.1074/jbc.M104207200. PubMed PMID: 11438536.

Balachandran S, Barber GN. Vesicular stomatitis virus (VSV) therapy of tumors. IUBMB Life. 2000 Aug;50(2):135-8. doi: 10.1080/713803696. PubMed PMID: 11185959.

Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR, Barber GN. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity. 2000 July ;13(1):129-41. PubMed PMID: 10933401.

Balachandran S, Roberts PC, Kipperman T, Bhalla KN, Compans RW, Archer DR, Barber GN. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. Journal of Virology. Feb 2000;74(3):1513-23. PubMed PMID: 10627563; PubMed Central PMCID: PMC111487.

Balachandran S, Kim CN, Yeh WC, Mak TW, Bhalla K, Barber GN. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. The EMBO journal. 1998;17(23):6888-902. doi: 10.1093/emboj/17.23.6888. PubMed PMID: 9843495; PubMed Central PMCID: PMC1171037.

Barber GN, Thompson S, Lee TG, Strom T, Jagus R, Darveau A, Katze MG. The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(10):4278-82. PubMed PMID: 7514301; PubMed Central PMCID: PMC43768.

Barber GN, Wambach M, Wong ML, Dever TE, Hinnebusch AG, Katze MG. Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. Proceedings of the National Academy of Sciences of the United States of America. May 1993;90(10):4621-5. PubMed PMID: 8099444; PubMed Central PMCID: PMC46564.

Hu SL, Abrams K, Barber GN, Moran P, Zarling JM, Langlois AJ, Kuller L, Morton WR, Benveniste RE. Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160. Science. Jan 1992;255(5043):456-9. PubMed PMID: 1531159.

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