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STING Pathway

The innate immune sensor STING and STING controlled cytosolic DNA innate immune signaling pathway was discovered by the laboratory of Glen N Barber (Nature, 2008).  STING senses cyclic dinucleotides (CDN’s) generated by intracellular bacteria or produced by cytosolic DNA species via a cellular CDN synthase, cGAS. STING agonists are potent activators of cytokine production which are essential for generating anti-microbial and anti-tumor immune responses. Stimulation of the STING pathway has been shown to exert potent anti-tumor immune responses and may have significant potential in anti-microbial treatments and as adjuvants for novel vaccine development.

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. 
Hiroki Ishikawa, Zhe Ma1, Glen N. Barber, Nature 2009

STING: Infection, Inflammation, and Cancer
 Glen N. Barber, Nature Reviews, Immunology 2015

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